Fotobiostimolazione: un nuovo strumento per il benessere del cervello e il sostegno all'intervento psicoterapeutico nei disturbi dell’umore.
Parole chiave:
Fotobiostimolazione, terapia laser a bassa potenza, malattie neurodegenerative, depressione, ansiaAbstract
La terapia di fotobiomodulazione attravero l’uso di laser a bassa potenza o LED ha accumulato un numero crescente di evidenze scientifiche in molti ambiti della sua applicazione in medicina. I suoi meccanismi di azione sono sempre più noti ed essendo un trattamento privo di effetti collaterali o avversi, che a volte può essere anche auto somministrato dai pazienti, presenta numerosi vantaggi e opportunità di cura. L’articolo presenta una rassegna di ricerche relative al suo utilizzo nell’ambito del trattamento delle malattie neurodegenerative e dei disturbi dell’umore, auspicandone lo sviluppo per una applicazione clinica efficace in un’ottica di intervento multidisciplinare, che tenga conto di una lettura sistemica di queste problematiche con un conseguente trattamento integrato delle stesse.
Riferimenti bibliografici
Barrett, D. W., & Gonzalez-Lima, F. (2013). Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans. Neuroscience, 230, 13-23.
Bastianelli L., Bianchi A., Bottaccioli F., et al., (2021) Un nuovo paradigma per le scienze e le professioni psicologiche e psichiatriche, Pnei Review, 1: pp. 12-69.
Bathini, M., Raghushaker, C.R. & Mahato, K.K. (2022) The Molecular Mechanisms of Action of Photobiomodulation Against Neurodegenerative Diseases: A Systematic Review. Cell Mol Neurobiol 42, 955–971. https://doi.org/10.1007/s10571-020-01016-9
Cardoso, FDS., Gonzalez-Lima, F., Gomes da Silva, S. (2021) Photobiomodulation for the aging brain, Ageing Research Reviews, Volume 70, 101415, ISSN 1568-1637, https://doi.org/10.1016/j.arr.2021.101415.
Cassano, P., Petrie, S. R., Mischoulon, D., Cusin, C., Katnani, H., Yeung, A., De Taboada, L., Archibald, A., Bui, E., Baer, L., Chang, T., Chen, J., Pedrelli, P., Fisher, L., Farabaugh, A., Hamblin, M. R., Alpert, J. E., Fava, M., & Iosifescu, D. V. (2018). Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder. The ELATED-2 Pilot Trial. Photomedicine and laser surgery, 36(12), 634–646. https://doi.org/10.1089/pho.2018.4490
Cassano P, Norton R, Caldieraro MA, Vahedifard F, Vizcaino F, McEachern KM, Iosifescu D. (2022) Tolerability and Safety of Transcranial Photobiomodulation for Mood and Anxiety Disorders. Photonics; 9(8):507. https://doi.org/10.3390/photonics9080507
Chung, H., Dai, T., Sharma, S.K. et al. (2012) The Nuts and Bolts of Low-level Laser (Light) Therapy. Ann Biomed Eng 40, 516–533. https://doi.org/10.1007/s10439-011-0454-7.
Doidge N. (2018). Le guarigioni del cervello. Le nuove strade della neuroplasticità: terapie rivoluzionarie che curano il nostro cervello. Milano: Ponte alle Grazie.
Hamblin M. R. (2016). Shining light on the head: Photobiomodulation for brain disorders. BBA clinical, 6, 113–124. https://doi.org/10.1016/j.bbacli.2016.09.002
Kahn, F., (2008) Low Intensity Laser Therapy - 3-Volume Boxed-Set. Dibo Canada. ISBN 978-0981770130
Karu, T. (2007). Ten Lectures on Basic Science of Laser Photo- therapy. Grängesberg, Sweden: Prima Books AB.
Karu T. (2010). Mitochondrial mechanisms of photobiomodulation in context of new data about multiple roles of ATP. Photomedicine and laser surgery, 28(2), 159–160. https://doi.org/10.1089/pho.2010.2789.
Liebert, A., Bicknell, B., Laakso, EL. et al. (2021) Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept study. BMC Neurol 21, 256. https://doi.org/10.1186/s12883-021-02248-y
Maiello, M., Losiewicz, O. M., Bui, E., Spera, V., Hamblin, M. R., Marques, L., & Cassano, P. (2019). Transcranial Photobiomodulation with Near-Infrared Light for Generalized Anxiety Disorder: A Pilot Study. Photobiomodulation, photomedicine, and laser surgery, 37(10), 644–650. https://doi.org/10.1089/photob.2019.4677
Montazeri, K., Farhadi, M., Fekrazad, R. et al. (2022) Photobiomodulation therapy in mood disorders: a systematic review. Lasers Med Sci ., 37, 3343–3351. https://doi.org/10.1007/s10103-022-03641-w.
Pan, Wt., Liu, Pm., Ma, D. et al. (2023) Advances in photobiomodulation for cognitive improvement by near-infrared derived multiple strategies. J Transl Med , 21, 135. https://doi.org/10.1186/s12967-023-03988-w
Passarella, S., & Karu, T. (2014). Absorption of monochromatic and narrow band radiation in the visible and near IR by both mitochondrial and non-mitochondrial photoacceptors results in photobiomodulation. Journal of photochemistry and photobiology. B, Biology, 140, 344–358. https://doi.org/10.1016/j.jphotobiol.2014.07.021
Salehpour, F., & Rasta, S. H. (2017). The potential of transcranial photobiomodulation therapy for treatment of major depressive disorder. Reviews in the neurosciences, 28(4), 441–453. https://doi.org/10.1515/revneuro-2016-0087.
Saltmarche, A., Naeser, M. A., Ho, K. F., Hamblin, M. R., & Lim, L. (2016). Significant improvement in cognition after transcranial and intranasal photobiomodulation: A controlled, single-blind pilot study in participants with dementia. In Poster presentato alla Alzheimer’s Association International Conference.
Schiffer, F., Johnston, A.L., Ravichandran, C. et al. (2009) Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety. Behav Brain Funct 5, 46. https://doi.org/10.1186/1744-9081-5-46
Stepanov, Y.V., Golovynska, I., Zhang, R. et al. (2022) Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer’s disease. Alz Res Therapy 14, 84. https://doi.org/10.1186/s13195-022-01022-7
Tuner J. Hode L. (2011) The laser therapy handbook. Grängesberg: Prima Books.
TRECCANI (2008) Enciclopedia della Scienza e della Tecnica. Mondadori.
Yang, L., Youngblood, H., Wu, C. et al. (2020) Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation. Translational Neurodegeneration 9, 19. https://doi.org/10.1186/s40035-020-00197-z
Valverde A, Mitrofanis (2022) J. Photobiomodulation for Hypertension and Alzheimer's Disease. J Alzheimers Dis;90(3):1045-1055. doi: 10.3233/JAD-220632. PMID: 36189597; PMCID: PMC9741744.
Vargas, E., Barrett, D. W., Saucedo, C. L., Huang, L., Abraham, J. A.,Tanaka, H., Haley, A. P., & Gonzalez-Lima, F. (2017). Beneficialneurocognitive effects of transcranial laser in older adults. Lasers in Medical Science, 32(5), 1153–1162.
Vieira, W. F., Iosifescu, D. V., McEachern, K. M., Gersten, M., & Cassano, P. (2023). Photobiomodulation: An Emerging Treatment Modality for Depression. Psychiatric Clinics of North America, 46(2), 331-348. https://doi.org/10.1016/j.psc.2023.02.013
Voineskos AN, Mulsant BH, Dickie EW, et al. (2020) Effects of Antipsychotic Medication on Brain Structure in Patients with Major Depressive Disorder and Psychotic Features: Neuroimaging Findings in the Context of a Randomized Placebo-Controlled Clinical Trial [published online ahead of print, 2020 Feb 26]. JAMA Psychiatry; 77(7):1-11. doi:10.1001/jamapsychiatry.2020.0036)
Waight, J.L., Arias, N., Jiménez-García, A.M. et al. From functional neuroimaging to neurostimulation: fNIRS devices as cognitive enhancers. Behav Res (2023). https://doi.org/10.3758/s13428-023-02144-y
Zomorrodi, R., Saltamarche, A., Loheswaran, G., et al. (2017) Complementary EEG Evidence for a Significantly Improved Alzheimer’s Disease Case after Photobiomodulation Treatment Poster presentato all’Alzheimer’s Association International Conference, July 14-20.
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